Analysis on Chinese Population with Pulmonary Tuberculosis

· Empirical Study, Volume 2 Issue 2

Meta-analysis on the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis

Authors: Su, Yong; Li, Ying; Sun, Guixiang

Abstract:

Objective: The current meta-analysis determined the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis.

Methods: The CBM, CNKI, and MEDLINE databases were retrieved by computers. Domestic and international documents involving studies on the relevance of HLA-DRB1 gene polymorphisms in a Chinese population with pulmonary tuberculosis were collected from the database until May 2013, and statistical analysis was performed on all of the eligible results with RevMan5.0 software.

Results: Eleven case-control studies were collected, including 1364 cases in the pulmonary tuberculosis group and 1496 cases in the control group. The consolidated OR values and 95% confidence intervals of the case and control groups of HLA-DRB1 *04, HLA-DRB1 *15, and HLA-DRB1 *16 were 1.32 (1.09–1.60), 1.40 (1.01–1.93), and 1.36 (1.01–1.83), respectively.

Conclusion: HLA-DRB1 *04, HLA-DRB1 *15, and HLA-DRB1 *16 may be susceptibility genes for pulmonary tuberculosis in a Chinese population.

Keywords: Pulmonary tuberculosis, HLA-DRB1 gene, Polymorphism, Meta-analysis

DOI: http://dx.doi.org/10.15212/FMCH.2014.0124

Affiliations: School of Public Health, Xuzhou Medical College, Xuzhou 221004, China